Figure 3From: Fibroblast Growth Factor 23 (FGF23) and Disorders of Phosphate MetabolismHeterotrimer complex of Klotho, FGF23, and FGFR1c. Klotho, FGF23, and FGFR1c make a heterotrimer complex in order to transmit the signal of FGF23 to target organs. Therefore, Klotho seems to be necessary for FGF23 signaling. N: N-terminus of FGF23 protein; C: C-terminus of FGF23 protein.Back to article page