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Table 1 Monitoring urea therapy.

From: Long-Term Outcomes in a Family with Nephrogenic Syndrome of Inappropriate Antidiuresis

Age (months)

3 (pre-urea therapy)

4

6 (intercurrent illness)

10

18

19

21

33

Serum Na (135–145 mmol/L)

124

139

118

136

140

137

138

139

Serum urea (2.0–6.7 mmol/L)

1.8

10.2

12.6

9.9

9.4

6.1

5.1

3.1

ADH (0.1–7.0 pmol/L)

0.6

—

—

—

—

—

—

1.2

Urea dose

1.5 g/kg/day, 6 divided doses

2 g/kg/day, 4 divided doses

2 g/kg/day, 4 divided doses

1.9 g/kg/day, 4 divided doses

1.2 g/kg/day, Weaning doses

Ceased

Nil

Nil

Fluid restriction

70 mL/kg/day

50 mL/kg/day

50 mL/kg/day

65 mL/kg/day (650 mL/day)

80 mL/kg/day (1000 mL/day)

80 mL/kg/day (1000 mL/day)

90 mL/kg/day (1200 mL/day)

75 mL/kg/day (1200 mL/day), increased to 94 mL/kg/day (1500 mL/day)