Class | Examples |
---|---|
Hormones | Insulin (e.g., Humulin), glucagon (e.g., Glucagen), human growth hormone (e.g., Humatrope), thyrotropin (Thyrogen), follicle-stimulating hormone (Gonal-F), lutelnizing hormone (lutropin alfa [Luveris]), human chorionic gonadotropin (Ovidrel), erythropoietin (e.g., epoctin alfa [Epogen]) |
Cytokines | Interferon alfa (e.g., Roferon-A), granulcyte-colony-stimulating factor (filgrastim [Neupogen]), interleukin (e.g., aldesleukin [Proleukin]) |
Clotting factors | Factor VII (NovoSeven), factor VIII (e.g., Kogenate), factor IX (BeneFIX) |
Monoclonal antibodies | Antibodies to vascular endothelial growth factor (bevacizumab [Avastin]), epidermal growth factor receptor (cetuximab [Erbitux]), GPIIb/IIIa receptor (abciximab [ReoPro]), CD20 (rituximab [Rituxan]), and TNF-α (e.g., infliximab [Remicade]) |
Vaccine products | Hepatitis B surface antigen (e.g., Recomblvax HB), Borrelia burgdorferi outer sourface protein A (LYMErix), + human papillomavirus major capsid proteins (Gardasil) |
Enzymes | Glucocerebrosidase (Cerezyme), DNase (Pulmozyme), thrombolytics (e.g., alteplase [Activase]), urate oxidase (rasburicase, Elitek) |
Ovel synthetic proteins | Fusion protein of interleukin-2 and diphtheria toxin (denileukin diftitox [Ontak]), soluble TNF receptor linked to IgG Fc (etanercept [Enbrel]) |
Novel conjugates | Pegylated proteins: interferon (peginterferon alfa-2a [Pegasys]), granulocyte colony-stimulating factor (pegfilgrastim [Neulasta]), human growth hormone (pegvisomant [Sornavert]) |
 | Covalently attached metal chelators: ibrutumomab tiuxetan (Zevalin) |
 | Covalently attached radioactive iodine: Iodine-131 tositumomab (Bexxar) |
 | Covalently attached chemotherapeutics: gemtuzumab ozogarnicin (Mylotarg) |