Transient Pseudohypoaldosteronism due to Urinary Tract Infection in Infancy: A Report of 4 Cases

Table 1 Characteristics and laboratory data of 4 infants with secondary pseudohypoaldosteronism.

Patient	Age at	Serum Na	Serum K	17-OH-P	Aldosterone	Urine Na	Urine	Renal imaging⁵
	presentation	(mmol/L)¹	(mmol/L)¹	(nmol/L)²	(nmol/L)³	(mmol/L)⁴	microbe
1	29 days	124	8.4	2.15 (71 ng/dL)	33.24 (1200 ng/dL)	54	Group B Streptococcus	Unilateral grade 3-4 VUR, mild pelviectasis
2	5 weeks	110	6.8	2.64 (87 ng/dL)	21.74 (785 ng/dL)	12	Klebsiella oxytoca	Unilateral hydronephrosis
3	7 months	116	6.7	0.69 (23 ng/dL)	28.67 (1035 ng/dL)	7	Klebsiella pneumoniae	Unilateral hydronephrosis and hydroureter
4	3 months	103	7.8	4.85 (160 ng/dL)	Not obtained	25	Klebsiella oxytoca	Resolution of previous hydronephrosis
4 (event 2)	7 months	111	5.6	Not obtained	9.62 (347 ng/dL)	21	Eschericia coli	Atrophic right upper pole versus pyelonephritis

¹Serum sodium and potassium values at the time of presentation to clinic or emergency room. ²17-OH-P = Serum 17-alpha hydroxyprogesterone. ³Normal range for serum aldosterone: .083–.44 nmol/L (3–16 ng/dL). ⁴Urinary sodium was obtained at least one day after the start of antibiotic therapy in all cases expect for Patient 1, in whom the urine sample was obtained the day of antibiotic initiation. ⁵Renal imaging included renal ultrasound, voiding cystourethrogram (VCUG), and in the case of patient 4 2nd visit, DMSA scan.

ISSN: 1687-9856