Table 3 Pediatric cohort studies of propylthiouracil-related adverse events.
From: Propylthiouracil (PTU) Hepatoxicity in Children and Recommendations for Discontinuation of Use
| Authors, year | N | AE (n) | % AE | Adverse events |
|---|---|---|---|---|
| Hamburger, 1985 [57] | 182 | 31 | 17% | 11 Cutaneous |
| 1 Cutaneous and neutropenia | ||||
| 1 Cutaneous and rheumatological | ||||
| 1 Cutaneous and hepatic | ||||
| 1 Cutaneous and pharyngitis | ||||
| 4 Neutropenia | ||||
| 2 Hepatic | ||||
| 1 Rheumatological | ||||
| 2 Nausea | ||||
| 5 Multiple infections without neutropenia | ||||
| 1 Unspecified | ||||
| Lippe et al., 1987 [59] | 63 | 1 | 1.5% | 1 Arthritic reaction |
| Ward et al., 1999 [62] | 33 | 8 | 24% | Rash, arthralgia, nausea, vomiting |
| Lazar et al., 2000 [63] | 28 | 14 | 35% | 2 Major; agranulocytosis; toxic hepatitis |
| 12 Minor | ||||
| Somnuke et al., 2007 [61] | 32 | 2 | 6% | ANCA; nephritis |
| Rash, arthralgia | ||||
| Glaser and Styne, 2008 [56] | 70 | 11 | 16% | 1 Rash |
| 2 Rash and arthralgia | ||||
| 1 Arthritis with purpura | ||||
| 1 Arthritis with purpura, hematuria | ||||
| 3 Elevated liver function tests | ||||
| 2 Marked elevated liver function tests | ||||
| 2 Neutropenia | ||||
| Ma et al., 2008 [60] | 40 | 8 | 20% | 6 Serious |
| 48 | 7 | 14.6% | NA |