Table 3 Pediatric cohort studies of propylthiouracil-related adverse events.

Hamburger, 1985 [57]

11 Cutaneous

1 Cutaneous and neutropenia

1 Cutaneous and rheumatological

1 Cutaneous and hepatic

1 Cutaneous and pharyngitis

4 Neutropenia

2 Hepatic

1 Rheumatological

2 Nausea

5 Multiple infections without neutropenia

1 Unspecified

Lippe et al., 1987 [59]

1 Arthritic reaction

Ward et al., 1999 [62]

Rash, arthralgia, nausea, vomiting

Lazar et al., 2000 [63]

2 Major; agranulocytosis; toxic hepatitis

12 Minor

Somnuke et al., 2007 [61]

ANCA; nephritis

Rash, arthralgia

Glaser and Styne, 2008 [56]

1 Rash

2 Rash and arthralgia

1 Arthritis with purpura

1 Arthritis with purpura, hematuria

3 Elevated liver function tests

2 Marked elevated liver function tests

2 Neutropenia

Ma et al., 2008 [60]

6 Serious

NA