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Table 3 Pediatric cohort studies of propylthiouracil-related adverse events.

From: Propylthiouracil (PTU) Hepatoxicity in Children and Recommendations for Discontinuation of Use

Authors, year N AE (n) % AE Adverse events
Hamburger, 1985 [57] 182 31 17% 11 Cutaneous
     1 Cutaneous and neutropenia
     1 Cutaneous and rheumatological
     1 Cutaneous and hepatic
     1 Cutaneous and pharyngitis
     4 Neutropenia
     2 Hepatic
     1 Rheumatological
     2 Nausea
     5 Multiple infections without neutropenia
     1 Unspecified
Lippe et al., 1987 [59] 63 1 1.5% 1 Arthritic reaction
Ward et al., 1999 [62] 33 8 24% Rash, arthralgia, nausea, vomiting
Lazar et al., 2000 [63] 28 14 35% 2 Major; agranulocytosis; toxic hepatitis
     12 Minor
Somnuke et al., 2007 [61] 32 2 6% ANCA; nephritis
     Rash, arthralgia
Glaser and Styne, 2008 [56] 70 11 16% 1 Rash
     2 Rash and arthralgia
     1 Arthritis with purpura
     1 Arthritis with purpura, hematuria
     3 Elevated liver function tests
     2 Marked elevated liver function tests
     2 Neutropenia
Ma et al., 2008 [60] 40 8 20% 6 Serious
  48 7 14.6% NA