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Table 2 Adverse events reported to the FDA from 1970 to 1997 in individuals ≤18 years of age.

From: Propylthiouracil (PTU) Hepatoxicity in Children and Recommendations for Discontinuation of Use

Adverse event Propylthiouracil Methimazole
Total number 34 14
Hospitalizations 18 3
Deaths 2 0
Liver injury: mild 1 0
Liver injury: serious 13 0
Liver transplantation 2 0
Liver injury-related death 2 0
Agranulocytosis 1 1
Leukopenia 3 1
Thrombocytopenia 1 0
Renal injury 3 0
Vasculitis 3 1
Arthritis 1 2
Arthralgia 1 1
Rash/urticaria 5 9