Table 2 Adverse events reported to the FDA from 1970 to 1997 in individuals ≤18 years of age.
From: Propylthiouracil (PTU) Hepatoxicity in Children and Recommendations for Discontinuation of Use
Adverse event | Propylthiouracil | Methimazole |
|---|---|---|
Total number | 34 | 14 |
Hospitalizations | 18 | 3 |
Deaths | 2 | 0 |
Liver injury: mild | 1 | 0 |
Liver injury: serious | 13 | 0 |
Liver transplantation | 2 | 0 |
Liver injury-related death | 2 | 0 |
Agranulocytosis | 1 | 1 |
Leukopenia | 3 | 1 |
Thrombocytopenia | 1 | 0 |
Renal injury | 3 | 0 |
Vasculitis | 3 | 1 |
Arthritis | 1 | 2 |
Arthralgia | 1 | 1 |
Rash/urticaria | 5 | 9 |