Skip to main content

Table 1 Case reports of propylthiouracil-related liver injury in pediatric patients.

From: Propylthiouracil (PTU) Hepatoxicity in Children and Recommendations for Discontinuation of Use

Authors, year Age (years) Gender Daily dose (mg) Duration of PTU Liver abnormality Outcome
Moore, 1946 [8] 12 F 300 0.5 months Liver injury Recovery
Parker, 1975 [12] 9 F 300 2 months Portal inflammation cholestasis Recovery
Reddy, 1979 [14] 10 F 300 1.2 months Hepatitis Recovery
Bloch et al., 1985 [21] 12 M 450 2 months Hepatitis Recovery
Garty et al., 1985 [22] 12 F 300 1 month Hepatitis Recovery
Limaye and Ruffolo, 1987 [24] 6 F 300 4 months Hepatitis Recovery
Jonas and Eidson, 1988 [25] 13 F 300 7 months Massive necrosis Death
Baker et al., 1989 [26] 9 F 300 3 months Hepatitis Recovery
Kirkland, 1990 [29] 9 F 300 4 months Liver failure Transplant/Recovery
Levy, 1993 [31] 11 F 300 14 months Liver failure Death
Deidiker and deMello, 1996 [41] 13 F 250 4 months Liver failure Transplant/Death
Williams et al., 1997 [43] 14 F 450 4 months Liver failure Transplant/Recovery
Testa et al., 2003 [35] 17 F 450 6 months Liver failure Transplant/Recovery
Sipe et al., 2006 [37] 7 F 300 9 months Liver failure Transplant/Recovery