Volume 2015 Supplement 1

Abstracts from the 8th APPES Biennial Scientific Meeting

Open Access

Study of serum visfatin and blood glucose and lipid metabolism, nafld in simple obese children

  • Rui-zhen Li1,
  • Hui-ling Lu2,
  • Xin-yu Ma1 and
  • Shi-xiu Kang1
International Journal of Pediatric Endocrinology20152015(Suppl 1):P74

https://doi.org/10.1186/1687-9856-2015-S1-P74

Published: 28 April 2015

Keywords

Visfatin Obesity Children Fatty liver

Aims

To investigate the relationships between serum visfatin and blood glucose and lipid metabolism, nonalcoholic fatty liver disease (NAFLD) in simple obese children.

Methods

Eighty-six children (57 boys and 29 girls) including 40 obese children, 22 overweight children and 24 healthy children were recruited with ages ranged 7-15 years.The serum visfatin levels were determined by ELISA.

Results

(1) As compared with normal and overweight children, serum visfatin levels increased 49.80%( P<0.05) and 35.88% (P<0.05); There were no difference of serum visfatin levels between the healthy and overweight children. (2) The body mass index, TC, TG, LDL-c, FPG, FINS and insulin resistance index of the obese children were higher than the healthy children (p<0.05 or p<0.01); the HDL-c and insulin sensitivity index of the obese children were lower than the healthy group (p<0.01 or p<0.05).The body mass index, the fasting insulin and the insulin resistance index of the obese children were higher than the overweight children (p<0.01).The ALT and AST levels of the obese children were higher than the healthy group (p<0.05).There was significant difference between the obese children and healthy children on the no-alcoholic fatty liver disease (p<0.01) with the prevalence of 23.33% and 5.26%, respectively.(3) Correlation analysis: Body mass index, TG and ALT were positively correlated serum visfatin (r=0.218, p<0.05; r=0.500, p<0.01; r=0.426, p<0.01, respectively).

Conclusions

The serum visfatin level is correlated with obesity and it is related with the disorder of lipid metabolism and the occurrence of fatty liver in obese children.Serum visfatin levels can be used as a new indicator to evaluate the trend of childhood obesity and valuate the risk of fatty liver, diabetes and cardiovascular of the obese children in the future.

Authors’ Affiliations

(1)
Children’s Hospital
(2)
TongJi Hospital Affiliated to TongJi Medical College of Huazhong University of Science and Technology

Copyright

© Li et al; licensee BioMed Central Ltd. 2015

This article is published under license to BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.

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