Volume 2015 Supplement 1

Abstracts from the 8th APPES Biennial Scientific Meeting

Open Access

A lack of association between vitamin d-binding protein and 25-hydroxyvitamin d concentrations in pediatric type 1 diabetes without microalbuminuria

  • Hwa Young Kim1,
  • Young Ah Lee1,
  • Hae Woon Jung1,
  • So Youn Kim1,
  • Kyung A Jeong1,
  • Keun Hee Choi1,
  • Jieun Lee2,
  • Ju Young Yoon3,
  • Sei Won Yang1 and
  • Choong Ho Shin1
International Journal of Pediatric Endocrinology20152015(Suppl 1):P16

DOI: 10.1186/1687-9856-2015-S1-P16

Published: 28 April 2015

The risk of vitamin D deficiency might increase along with the increased urinary loss of vitamin D binding protein (VDBP) consequent to impaired 25-hydroxyvitaminD (25-OHD) circulation. We aimed to evaluate the possible increased urinary loss of VDBP, a correlation between VDBP and circulating 25-OHD levels, and the risk factors influencing low vitamin D levels in pediatric type 1 diabetes patients without microalbuminuria.

Subjects with T1DM without microalbuminuria (n=45) and age-matched healthy control subjects (n=29), aged 9–14 yr, residing in Seoul and the Gyeonggi-Do in Korea (37°N) were studied. Height, weight and pubertal stage were evaluated. The percentage of body fat was measured by bioelectrical impedance analysis (inbody). A questionnaire was used to assess the amount of daylight outdoor activity and vitamin D intake. Serum levels of calcium, phosphorus, intact parathyroid hormone, 25-OHD, 1,25 dihydroxyvitamin D and VDBP, as well as urinary levels of VDBP, microalbumin and creatinine (Cr) were measured. 25-OHD deficiency was defined as ≤20 ng/mL.

The urinary VDBP to Cr ratio (VDBPCR) in type 1 diabetes patients was higher than that in the control group (P = 0.016) and correlated positively with the urinary microalbumin to Cr ratio in both groups (P <0.001). The serum 25-OHD levels did not correlate with the serum VDBP or urinary VDBPCR. A multivariate regression analysis including known vitamin D deficiency risk factors (age, gender, body fat percentage, vitamin D intake, daylight outdoor hours, and urinary VDBPCR) revealed that daylight outdoor hours (β = 2.881, P = 0.009) and vitamin D intake (β = 2.342, P = 0.050) affected the 25-OHD levels in type 1 diabetes patients.

In pediatric type 1 diabetes patients without microalbuminuria, the urinary VDBP loss was increased proportionally with the urinary mACR. However, the urinary VDBPCR did not correlate with the serum 25-OHD levels. The factors associated with 25-OHD levels during winter periods were daylight outdoor hours and vitamin D intake.

Authors’ Affiliations

(1)
Department of Pediatrics, Seoul National University College of Medicine
(2)
Department of Pediatrics, Sungkyunkwan University College of Medicine, Samsung Medical Center
(3)
Center for Pediatric Oncology, National Cancer Center

Copyright

© Kim et al; licensee BioMed Central Ltd. 2015

This article is published under license to BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.

Advertisement