Volume 2015 Supplement 1

Abstracts from the 8th APPES Biennial Scientific Meeting

Open Access

LGA infants display early catch down growth in length and weight without epigenetic changes

  • Valentina Chiavaroli1,
  • Wayne Cutfield1,
  • José Derraik1,
  • Pan Zengxiang1,
  • Sherry Ngo1,
  • Allan Sheppard1,
  • Susan Craigie1 and
  • Fredrik Ahlsson1, 2
International Journal of Pediatric Endocrinology20152015(Suppl 1):P106

DOI: 10.1186/1687-9856-2015-S1-P106

Published: 28 April 2015

Aims

To evaluate the growth patterns of infants born large-for-gestational-age (LGA) from birth to age 1 year compared to those born appropriate-for-gestational-age (AGA). In addition, we aimed to investigate possible epigenetic changes associated with being born LGA.

Methods

Seventy-one singleton infants born at term were classified by birth weight as AGA (10th-90th percentile; n=42) and as LGA (>90th percentile; n=29). Post-natal follow-up until age 1 year was performed with clinical assessments at 3, 6, and 12 months. Assessments included measurement of infants’ weight, length, ponderal index, BMI, as well as head, chest, and abdominal circumference. A subgroup of 38 infants (17 AGA and 21 LGA) was selected for genome-wide DNA methylation analysis. Umbilical cord was collected at birth, and methylation profile on umbilical tissue was analysed using the Illumina Infinium 450K methylation array.

Results

At birth, the LGA group had greater birth weight (P<0.0001), length (P<0.0001), head circumference (P<0.0001), ponderal index (P=0.02), BMI (P<0.0001), chest and abdominal circumferences (P=0.04 and P=0.007, respectively) than AGA newborns. At the age of 3 months, LGA infants still presented greater weight (P<0.0001), length (P=0.006), BMI (P=0.02), as well as head (P=0.004) and abdominal (P=0.04) circumferences than AGA peers. However, by age 6 months there were no more anthropometric differences between the two groups. This was due to higher length increment in AGA than LGA infants between 0-6 months (18.3 vs 15.1 cm; P<0.0001), whereas length increment was identical in both groups between 6-12 months (7.7 vs 7.7 cm; P=0.96). For the genome-wide analysis, more than 485,000 DNA methylation sites covering 99% of human NCBI Reference Sequence (RefSeq) genes were examined at birth, but no differences were found between LGA and AGA infants.

Conclusion

Despite being born oversized at birth, LGA infants displayed early catch-down growth (i.e. slower length velocity), so that by the age of 6 months LGA infants were of similar length and BMI as AGA infants. In addition, no epigenetic differences in genome-wide methylation were found in those born LGA.

Authors’ Affiliations

(1)
Liggins Institute, University of Auckland
(2)
Department of Women's and Children's Health, Uppsala University

Copyright

© Chiavaroli et al; licensee BioMed Central Ltd. 2015

This article is published under license to BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.

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