Volume 2015 Supplement 1

Abstracts from the 8th APPES Biennial Scientific Meeting

Open Access

Child growth trajectories to adult disease: lessons from UK birth cohort studies

  • Ken K. Ong1
International Journal of Pediatric Endocrinology20152015(Suppl 1):O1

DOI: 10.1186/1687-9856-2015-S1-O1

Published: 28 April 2015

The developmental origins of health and disease theory purports that early life factors determine long-term risks of death and disease. Historical studies, prospective birth cohorts such the UK ALSPAC birth cohort [1], and more recently genetic studies [2] indicate that the rapid weight gain trajectory to later obesity starts in the first months of life, even from birth. Rapid infant weight gain and childhood overweight lead to earlier pubertal maturation in boys and girls, and in turn these adolescent traits are predictive for obesity, diabetes, hypertension and cardiovascular disease events in later life. Understanding of the nutritional, parental and wider determinants of rapid infant weight gain are informing the development of obesity prevention strategies starting in early life [3].

In contrast to the above ‘rapid growth tempo’ trajectory to later disease, poor childhood growth is also a risk factor for later health and survival. This ‘early childhood stunting’ trajectory is seen in older UK birth cohorts, such as the 1946 British Birth Cohort Study [4], and is likely relevant to current children in lower and middle-income countries. The relative importance of these distinct childhood trajectories for later health likely depends on the prevailing nutritional environment. However, in those populations that are undergoing rapid nutritional transition from under- to over-nutrition, the adverse combination of early childhood stunting followed by transition to overweight and obesity will be particularly detrimental to later health.

Authors’ Affiliations

(1)
MRC Epidemiology Unit, Institute of Metabolic Science, University of Cambridge

References

  1. Ong KK, Ahmed ML, Emmett PM, Preece MA, Dunger DB: Association between postnatal catch-up growth and obesity in childhood: prospective cohort study. BMJ. 2000, 320 (7240): 967-971. 10.1136/bmj.320.7240.967.PubMed CentralView ArticlePubMedGoogle Scholar
  2. Elks CE, Loos RJ, Sharp SJ, Langenberg C, Ring SM, Timpson NJ, et al: Genetic markers of adult obesity risk are associated with greater early infancy weight gain and growth. PLoS Med. 2010, 7 (5): e1000284-10.1371/journal.pmed.1000284.PubMed CentralView ArticlePubMedGoogle Scholar
  3. Lakshman R, Elks CE, Ong KK: Childhood obesity. Circulation. 2012, 126 (14): 1770-1779. 10.1161/CIRCULATIONAHA.111.047738.PubMed CentralView ArticlePubMedGoogle Scholar
  4. Ong KK, Hardy R, Shah I, Kuh D, National Survey of Health and Development Scientific and Data Collection Teams: Childhood stunting and mortality between 36 and 64 years: the British 1946 Birth Cohort Study. J Clin Endocrinol Metab. 2013, 98 (5): 2070-2077. 10.1210/jc.2012-3595.PubMed CentralView ArticlePubMedGoogle Scholar

Copyright

© Ong; licensee BioMed Central Ltd. 2015

This article is published under license to BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.

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