Correlation of leptin, neuropeptide Y and amylin in childhood obesity

Purpose

To investigate the correlation of the serum leptin, NPY, amylin in the childhood obesity.

Methods

The body mass index (BMI), waist and hip circumference, blood pressure (systolic/diastolic), lipid profile, fasting glucose, insulin, leptin, neuropeptide Y(NPY), amylin were measured in 56 children (24 obese children and 32 non-obese controls). We calculated HOMA-IR and evaluated the relationship between each anthropometric data, metabolic bio-marker and diet regulating factor (leptin, NPY, amylin).

Results

Insulin and total cholesterol, triglyceride, LDL-cholesterol levels of the obese group were significantly higher than those of the non-obese group (p<0.05). leptin, NPY, leptin/NPY ratio, amylin levels of the obese group were significantly higher than those of the non-obese group (p<0.05). leptin showed significant correlation with BMI (r= 0.379, p= 0.043), NPY (r= 0.377, p= 0.044), L/N ratio (r= 0.754, p= 0.000) in the obese group. amylin showed significant correlation with insulin (r= 0.400, p= 0.048), HOMA-IR (r= 0.459, p= 0.028) in the obese group.

Conclusion

There is abnormality in central diet regulatory system caused by leptin and neuropeptide Y resistance in the obese group. And amylin showed significant correlation with insulin resistance