Volume 2013 Supplement 1

7th Asia Pacific Paediatric Endocrine Society (APPES) Biennial Scientific Meeting

Open Access

Correlation of leptin, neuropeptide Y and amylin in childhood obesity

  • Eun Young Kim1,
  • Sei Young Kim2,
  • Min Seon Choi1 and
  • Kyung Hee Yi3
International Journal of Pediatric Endocrinology20132013(Suppl 1):P97

DOI: 10.1186/1687-9856-2013-S1-P97

Published: 3 October 2013

Purpose

To investigate the correlation of the serum leptin, NPY, amylin in the childhood obesity.

Methods

The body mass index (BMI), waist and hip circumference, blood pressure (systolic/diastolic), lipid profile, fasting glucose, insulin, leptin, neuropeptide Y(NPY), amylin were measured in 56 children (24 obese children and 32 non-obese controls). We calculated HOMA-IR and evaluated the relationship between each anthropometric data, metabolic bio-marker and diet regulating factor (leptin, NPY, amylin).

Results

Insulin and total cholesterol, triglyceride, LDL-cholesterol levels of the obese group were significantly higher than those of the non-obese group (p<0.05). leptin, NPY, leptin/NPY ratio, amylin levels of the obese group were significantly higher than those of the non-obese group (p<0.05). leptin showed significant correlation with BMI (r= 0.379, p= 0.043), NPY (r= 0.377, p= 0.044), L/N ratio (r= 0.754, p= 0.000) in the obese group. amylin showed significant correlation with insulin (r= 0.400, p= 0.048), HOMA-IR (r= 0.459, p= 0.028) in the obese group.

Conclusion

There is abnormality in central diet regulatory system caused by leptin and neuropeptide Y resistance in the obese group. And amylin showed significant correlation with insulin resistance

Authors’ Affiliations

(1)
Department of Pediatrics, Chosun University School of Medicine
(2)
Department of Pediatrics, Daejin Medical Center
(3)
Department of Pediatrics, Wonkwang University Sabon Medical Center

Copyright

© Kim et al; licensee BioMed Central Ltd. 2013

This article is published under license to BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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