Volume 2013 Supplement 1

7th Asia Pacific Paediatric Endocrine Society (APPES) Biennial Scientific Meeting

Open Access

The effect of Vitamin C supplementation toward high sensitivity c-reactive protein (hsC-RP) level on male adolescent obesity in Padang

  • Nedi Hidayat1,
  • Eka Agustia Rini1 and
  • Rizanda Machmud1
International Journal of Pediatric Endocrinology20132013(Suppl 1):P85

DOI: 10.1186/1687-9856-2013-S1-P85

Published: 3 October 2013

Background

Prevalence of obesity in children and adolescent has significantly increased, it becomes a serious problem because of the over- releasing of interleukin-6 (IL-6), disruption on the oxidative balance, risk factor of getting cardiovascular disease with typically marked by elevation of the hight sensitivity C-Reactive Protein (hsC-RP). On the way to decrease IL-6 release from the visceral adipose cell is by treating the oxidative stress with antioxidant agent, such as Vitamin C.

Objective

To examine mean hsC-RP level on male adolescent obesity in Padang and to know the effect of Vitamin C supplementation toward hsC-RP level on male adolescent obesity in Padang.

Method

This is an experimental double blind study with 40 samples on March until May 2011, which were divided into 2 groups. One group consumed Vitamin C 500 mg and another group consumed placebo, both twice a day for 8 weeks. The hsC-RP level is measured before and after drug consumptions. The data were analyzed with chi-square and general liniear model repeated measure, the confidence interval, p<0.05.

Result

The mean of initial hsC-RP level is higher in the Vitamin C group than the placebo group ((2.28+ 1.51 vs 1.78+ 1.23 mg/L). At the end of the study, mean hsC-RP level were decreasing in both groups (1.09+ 1.13 vs 0.89+ 1.09 mg/L). The changing in hsC-RP level after 8 weeks isn’t significant statistically (p=0.481).

Conclusion

The mean hsC-RP level is high and Vitamin C supplementation was not significantly decreasing hsC-RP level on male adolescent obesity in Padang.

Authors’ Affiliations

(1)
Endocrinology Division, Pediatric Health Departement of Medical Faculty Andalas University, Dr. M. Djamil Hospital

Copyright

© Hidayat et al; licensee BioMed Central Ltd. 2013

This article is published under license to BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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