The role of continuous glucose monitoring in the care of children with type 1 diabetes
© Larson and Pinsker; licensee BioMed Central Ltd. 2013
Received: 15 March 2013
Accepted: 20 March 2013
Published: 26 March 2013
Continuous glucose monitoring (CGM), while a relatively new technology, has the potential to transform care for children with type 1 diabetes. Some, but not all studies, have shown that CGM can significantly improve hemoglobin A1c levels and reduce time spent in the hypoglycemic range in children, particularly when used as part of sensor-augmented pump (SAP) therapy. Despite the publication of recent clinical practice guidelines suggesting CGM be offered to all children 8 years of age or older who are likely to benefit, and studies showing that younger children can also benefit, this technology is not yet commonly used by children with type 1 diabetes. Effects of CGM are enhanced when used on a near-daily basis (a use-dependent effect) and with insulin pump therapy. Therefore, coordinated strategies are needed to help children and their families initiate and continue to use this resource for diabetes care. This review introduces CGM to pediatric endocrinologists who are not yet familiar with the finer details of this technology, summarizes current data showing the benefits and limitations of CGM use in children, reviews specific case examples demonstrating when CGM can be helpful, and shows the value of both retrospective and real-time CGM. It is hoped that this information leads to discussion of this technology in pediatric endocrinology clinics as an important next step in improving the care of children with type 1 diabetes.
KeywordsAdolescents Children Continuous glucose monitoring Diabetes Type 1 diabetes
Continuous glucose monitoring (CGM) has been shown to be helpful in adults with diabetes and offers the potential to improve care for children with type 1 diabetes (T1D) beyond what can be achieved with self-monitoring of blood glucose (SMBG) alone. The Endocrine Society now recommends CGM use starting at 8 years of age for anyone with T1D able to use it on a near-daily basis. Still, despite frequent use in large diabetes centers, CGM is not commonly used for pediatric patients with T1D [1, 2]. One reason for this is a lack of infrastructure and personnel qualified to teach patients, as access to a multidisciplinary trained team needed to teach families to use CGM effectively is generally not available to the non-academic pediatric endocrinologist [2, 3]. In addition, there is concern among providers about being overwhelmed by the considerable amount of data obtained , and about limited reimbursement for time spent interpreting the data .
Previous reports show that fewer than 30% of children with T1D have a hemoglobin A1c (HbA1c) less than 8%, and children experience episodes of severe hypoglycemia more frequently than adults . Accordingly, there is increasing interest among pediatric endocrinologists in using CGM to improve HbA1c levels and reduce the incidence of hypoglycemia in children. This corresponds with patient/family interest in CGM as a means to prevent hypoglycemia primarily, and improve diabetes control secondarily . The full clinical potential impact of CGM, however, is far from being realized since most children with T1D do not use or have access to this resource for their diabetes care . A major barrier for patients is that frequent use is required, with studies showing that both adults and children only benefit significantly if CGM is used more than 70% of the time (≥ 5 days per week) . In addition, there are important limitations to CGM (such as inconsistency in both accuracy and precision when measuring low blood sugars), and clinicians who do not routinely use CGM may feel ill-equipped to educate patients properly on these limitations . Identifying which children with T1D should use CGM has proven difficult and requires teaching families that CGM requires intensive management and will not replace time-consuming SMBG.
This review introduces CGM to clinicians who are not yet familiar with the details of the technology and summarizes current data showing the benefits and limitations of CGM use in children. Specific case examples are provided that demonstrate when CGM can be helpful and illustrate distinct qualities of both retrospective and real-time (RT) CGM. It is hoped that this information fosters discussion of use of this technology in pediatric endocrinology clinics that have not been routinely using this resource for the care of children with T1D.
The current state of CGM use in children with T1D
CGM is currently available in the United States (US) in 2 forms: Retrospective and RT. The only fully retrospective CGM system on the market in the US is the iPro 2 (Medtronic Diabetes). The iPro 2 measures interstitial fluid (IF) glucose levels using a subcutaneous electrode for up to 72 hours and does not require active calibration during its use. In Europe, an additional system, the GlucoDay S (A. Menarini Diagnostics), is also approved. Both systems are referred to as “professional CGM” meaning that devices are owned by the clinic and are inserted at a clinic appointment. Data obtained by CGM is this setting is blinded and only available to view after the device and the patient’s blood glucose meter are downloaded in the clinic. The graphs and summary data generated can help patients and diabetes team members adjust their therapy. Small trials in children have shown these retrospective devices to be helpful in identifying post-prandial hyperglycemia and asymptomatic overnight hypoglycemia [10–12].
Differences in blood sugar readings from the CGM and blood glucose meters, and the “false alarms” that result, can be frustrating to patients and their families . The mean absolute relative difference (MARD) between sensor readings and reference glucose levels can vary by as much as 20%; such variations are especially troubling in the hypoglycemic range [14–16]. The latest generation of sensors from Medtronic (Enlite sensor – not yet FDA approved in the US) and DexCom (G4 sensor) report shorter lag times and further improvement in accuracy, especially in the hypoglycemic range [17, 18]. It is important to emphasize to families that despite improvements in sensor accuracy, FDA approval for CGM devices in the US includes the recommendation that all treatment decisions (i.e., treating suspected low or high blood glucose) be based on fingerstick blood glucose, not sensor readings.
CGM devices can be used with an insulin pump as part of sensor-augmented pump (SAP) therapy or with multiple daily injections. Some systems are fully integrated into an insulin pump and use the pump display to show CGM readings (Figure 2). The Medtronic Paradigm Veo is currently the only system that includes a low glucose suspend feature that can be set to halt insulin delivery when glucose levels decline to a preset hypoglycemic threshold as determined by CGM. The sensors are approved to last only 3, 6, or 7 days, depending on the manufacturer. Thus far, off-label pediatric use of all of these systems is common.
How can CGM help pediatric patients with T1D?
The following examples show typical blood sugar pattern problems in children with T1D, often missed by SMBG, that became apparent with CGM.
Case 1 – detection and treatment of hyperglycemia
Can CGM use consistently improve HbA1c in children, particularly in patients, such as the one presented above, who already demonstrate good glycemic control? Meta-analyses of studies concluded prior to 2008 showed that CGM use was not superior to SMBG with regard to metabolic control among pediatric patients with T1D [19, 20]. Similar results were reported from the 2008 landmark Juvenile Diabetes Research Foundation CGM randomized controlled trial, in which overall blood glucose control in children ages 8–17 years old assigned to the CGM group did not differ from the SMBG group. However, a subsequent sub-group analysis revealed that, for the 21% of children who used CGM 6+ days a week, HbA1c levels were lowered by 0.8% without an increase in hypoglycemia . Subsequently, two multicenter, randomized controlled trials of adults and children with good control (HbA1c < 7.0% and 7.5%, respectively) demonstrated that RT-CGM use was associated with a mean improvement of −0.3% in HbA1c, suggesting CGM use could benefit patients whose HbA1c levels were already near their target range [22, 23]. Other recent studies also support the effectiveness of frequent use of CGM in lowering HbA1c levels in children with T1D, and suggest SAP therapy may offer the most benefit to children [24–28].
Case 2 – detection and correction of unrecognized hypoglycemia
Fear of hypoglycemia limits many children from attaining desired HbA1c goals . For many children with T1D, bedtime blood glucose checks are poor predictors of nocturnal hypoglycemia [10, 11, 30]. As noted in the 2012 consensus guideline for pediatric CGM, intermittent use of CGM (as demonstrated by the case history above) may detect the dawn phenomenon, postprandial hyperglycemia, asymptomatic daytime and unrecognized nocturnal hypoglycemia, and can aid in evaluating the effects of changes in treatment regimens . However, initial studies of RT-CGM suggested that its use did not reduce rates of hypoglycemia . The STAR1 trial of children using SAP therapy identified “failure to respond to high and low alarms, and/or appropriately dose and administer insulin,” as the main contributor to significantly higher rates of hypoglycemia . The conclusion, therefore, is not that RT-CGM cannot reduce hypoglycemia in patients using insulin pumps, but rather that it needs to be used properly. More recently, multicenter, randomized controlled trials (discussed above, showing that RT-CGM use lowered HbA1c levels in adults and children with good baseline blood sugar control), demonstrated that CGM use was associated with reduced rates of hypoglycemia in both adults and children [22, 23]. Further, in the last year, two industry-sponsored trials have shown significant improvements in HbA1c levels in children while also reducing time spent with blood sugar levels in the hypoglycemia range. The STAR3 trial of children using CGM showed a reduction in blood sugar level variability, favoring SAP use . In addition, the SWITCH Study Group’s trial of children and adults showed that, in patients using SAP therapy, HbA1c levels, as well as time spent with blood sugar levels in the hypoglycemia range, were reduced. .
Greater reductions in frequency and severity of hypoglycemia are likely with further integration of CGM into the insulin pump, as now seen with the Medtronic Paradigm Veo. Retrospective analyses of children and adults using the “low glucose suspend” feature of the Paradigm Veo, which automatically suspends insulin delivery for up to 2 hours after a hypoglycemic event occurs as determined by CGM, have shown both significant reductions in exposure to hypoglycemia and prevention of profound rebound hyperglycemia after the CGM system had automatically suspended insulin delivery for up to 2 hours [33, 34].
Case 3 – glycemic variability with exercise
CGM is a potentially powerful tool for athletes with T1D. In one study of long distance runners, CGM identified frequent hypo- and hyperglycemic episodes during and after races . CGM can be applied to any of the multiple strategies used to adjust insulin for strenuous exercise, helping to customize an exercise plan for each individual patient. For example, responding to CGM “rate-of-change in blood sugar level alerts” by ingesting extra carbohydrates per a preset algorithm has been shown to help adolescents prevent exercise induced hypoglycemia . Similarly, the low glucose suspend feature (described above) of the Medtronic Paradigm Veo has been shown to significantly reduce the duration and severity of exercise-induced hypoglycemia in adults, without causing significant rebound hyperglycemia .
As with any technological aid for diabetes, the major issue with CGM is encouraging consistent use . While early acceptance of CGM is predictive of extended use,  children in particular show waning adherence over time. It is important for families to understand at the outset of CGM use that this technology will not reduce the need to invest effort in diabetes management. In fact, use of RT-CGM is often more time consuming for patients because it forces them to constantly focus on diabetes care [13, 42]. Consequently, it is important to offer achievable plans with realistic expectations for patients so they can experience some successes with the technology from the start. Targeting of CGM to patients and families can also be enhanced by offering in-clinic use of retrospective CGM to allow patients to try CGM without fully committing to it. Those who find it helpful can then be offered RT-CGM for personal use.
It is also important for clinics themselves to have realistic objectives regarding CGM implementation. Larger centers with “diabetes technology clinics” typically start only a few children per month on CGM due to the time and resources needed for training . Some clinics offer classes that introduce the concept of CGM, provide hands-on exposure to the equipment, and then prescribe CGM for patients and families expressing interest and motivation. Use of standard reference materials (e.g. “Understanding Insulin Pumps and Continuous Glucose Monitors” ) is recommended as a curriculum to teach families to advance from insulin pump to SAP therapy. Instruction of families in the use of evidence-based algorithms to adjust their insulin regimen can also be extremely helpful. One model is to use the rate of change of glucose levels to alter the pre-meal bolus, with a change of 1–2 mg/dL/min indicating the need for a 10% adjustment in bolus dosing (up or down), and adjusting the bolus dose by 20% when the CGM system alerts that glucose levels are changing by more than 2 mg/dL/min [3, 44]. (In smaller children who exhibit greater insulin sensitivity, these percentages may need downward adjustment to 5% and 10%, respectively). With this strategy, patients immediately see that CGM enables use of dynamic data to adjust their plan of care beyond what was previously offered by SMBG.
The cost of CGM remains a significant obstacle. It has been estimated that CGM sensors cost over $4,000 per person year in the US . Although some insurance companies now provide reimbursement for these devices, particularly in patients with frequent hypoglycemia, coverage for CGM overall remains inconsistent. In addition, payment to providers for initiating CGM and interpreting data remains challenging. Clinicians can claim reimbursement in the US for the initiation of CGM and interpretation of CGM data using Current Procedural Terminology codes 95250 and 95251, although there are strict limitations on the use of these procedure codes amongst different insurers . Other countries have different fee structures, with some European countries now routinely covering retrospective CGM up to 4 times per year [5, 46].
Many additional challenges remain before CGM can be offered routinely to all children. While patient and family motivation predicts continued use , even the most motivated families often report using CGM only intermittently, despite recommendations for continuous wear, due to inability to tolerate the large size of the sensors and transmitters. Proper orientation regarding differences between devices and the advantages and disadvantages of each system is therefore very important (Figures 1 and 2). Even after all of the data has been presented, there are occasions where CGM identifies erratic glycemic control without an obvious pattern. When this occurs in patients who are already compliant with their care plan, it may not be clear as to what intervention will fix the underlying problem. These issues can potentially discourage clinics from supporting CGM in any form. Other challenges include finding the right combination of adhesive and skin site preparation with sensors sometimes falling off early or causing excessive skin irritation [13, 47], and “nuisance alarms” that interfere with daily activities. These alarms may go off in the middle of the night for low or high blood sugars and may not correlate with blood glucose meter readings or be set at appropriate thresholds . Because there can be a very large error rate for modern CGM systems at extreme but clinically relevant glucose concentrations, particularly for glucose values < 70 mg/dL when the glucose is changing rapidly , patients and families must be made aware of the limitations of the device they are using.
Common problems seen when starting CGM in children and adolescents, and potential solutions
• Painful sensor insertions.
• Apply a lidocaine-based cream 45 to 60 minutes prior to insertion.
• Apply a cool pack prior to insertion (may increase the risk of bleeding at the insertion site).
• Sensors do not adhere to the skin or cause irritation.
• Different tapes and wraps may need to be used.
• Tegaderm, or a moleskin tape (Duoderm), can be placed under the sensor and transmitter to act as a barrier.
• Too many “nuisance alarms” that do not agree with SMBG.
• Explain the concept of “lag time” upfront.
• Limit calibration to times when blood glucose levels are not changing rapidly.
• Lower alarm threshold to 70 mg/dL, and use only the low glucose alarm when first starting CGM.
CGM has the potential to transform care for children with T1D, particularly when used as part of SAP therapy. Consensus guidelines now exist to help physicians choose the appropriate pediatric patient for CGM use . These guidelines encourage discussion with patients to provide realistic expectations, understand limitations, and target use of specific features of CGM that allow for maximizing patient benefit. Recent advances such as the low glucose suspend feature of the Medtronic Paradigm Veo show that the first step in “closing the loop,” with CGM sensors directing insulin delivery from the insulin pump, has already begun. Advancement in CGM-linked smart telemedicine systems [4, 49], computerized analysis of CGM data , and smaller insertion needles and devices should ultimately allow pediatric endocrinologists to offer routine use of CGM to all children with T1D.
Written informed consent was obtained from the patients for publication of this report and any accompanying images.
Continuous glucose monitoring
Food and drug administration
Mean absolute relative difference
Self-monitoring of blood glucose
Type 1 diabetes
The authors thank Dr. Martin Weisse, Dr. Daniel Roy, Dr. Michael Ching and Dr. David F. Crudo for their critical review of the text. We also thank Dr. C. Becket Mahnke for his assistance preparing the figures.
The views expressed in this manuscript are those of the author and do not reflect the official policy or position of the Department of the Army, Department of Defense, or the U.S. Government.
- Klonoff DC, Buckingham B, Christiansen JS, Montori VM, Tamborlane WV, Vigersky RA, Wolpert H: Continuous glucose monitoring: an endocrine society clinical practice guideline. J Clin Endocrinol Metab. 2011, 96: 2968-2979. 10.1210/jc.2010-2756.View ArticlePubMed
- Phillip M, Danne T, Shalitin S, Buckingham B, Laffel L, Tamborlane W, Battelino T: Use of continuous glucose monitoring in children and adolescents (*). Pediatr Diabetes. 2012, 13: 215-228. 10.1111/j.1399-5448.2011.00849.x.View ArticlePubMed
- Hirsch IB: Clinical review: Realistic expectations and practical use of continuous glucose monitoring for the endocrinologist. J Clin Endocrinol Metab. 2009, 94: 2232-2238. 10.1210/jc.2008-2625.View ArticlePubMed
- Rigla M: Smart telemedicine support for continuous glucose monitoring: the embryo of a future global agent for diabetes care. J Diabetes Sci Technol. 2011, 5: 63-67.PubMed CentralView ArticlePubMed
- Heinemann L, Franc S, Phillip M, Battelino T, Ampudia-Blasco F, Bolinder J, Diem P, Pickup J, Hans DeVries J: Reimbursement for continuous glucose monitoring: a European view. J Diabetes Sci Technol. 2012, 6: 1498-1502.PubMed CentralView ArticlePubMed
- Ellis SL, Naik RG, Gemperline K, Garg SK: Use of continuous glucose monitoring in patients with type 1 diabetes. Curr Diabetes Rev. 2008, 4: 207-217. 10.2174/157339908785294370.View ArticlePubMed
- Cemeroglu AP, Stone R, Kleis L, Racine MS, Postellon DC, Wood MA: Use of a real-time continuous glucose monitoring system in children and young adults on insulin pump therapy: patients’ and caregivers’ perception of benefit. Pediatr Diabetes. 2010, 11: 182-187.View ArticlePubMed
- Raccah D, Sulmont V, Reznik Y, Guerci B, Renard E, Hanaire H, Jeandidier N, Nicolino M: Incremental value of continuous glucose monitoring when starting pump therapy in patients with poorly controlled type 1 diabetes: the RealTrend study. Diabetes Care. 2009, 32: 2245-2250. 10.2337/dc09-0750.PubMed CentralView ArticlePubMed
- Francescato MP, Geat M, Stel G, Cauci S: Accuracy of a portable glucose meter and of a Continuous Glucose Monitoring device used at home by patients with type 1 diabetes. Clin Chim Acta. 2012, 413: 312-318. 10.1016/j.cca.2011.10.012.View ArticlePubMed
- Gandrud LM, Xing D, Kollman C, Block JM, Kunselman B, Wilson DM, Buckingham BA: The Medtronic Minimed Gold continuous glucose monitoring system: an effective means to discover hypo- and hyperglycemia in children under 7 years of age. Diabetes Technol Ther. 2007, 9: 307-316. 10.1089/dia.2007.0026.View ArticlePubMed
- Schiaffini R, Ciampalini P, Fierabracci A, Spera S, Borrelli P, Bottazzo GF, Crino A: The Continuous Glucose Monitoring System (CGMS) in type 1 diabetic children is the way to reduce hypoglycemic risk. Diabetes Metab Res Rev. 2002, 18: 324-329. 10.1002/dmrr.309.View ArticlePubMed
- Maia FF, Araujo LR: Efficacy of continuous glucose monitoring system (CGMS) to detect postprandial hyperglycemia and unrecognized hypoglycemia in type 1 diabetic patients. Diabetes Res Clin Pract. 2007, 75: 30-34. 10.1016/j.diabres.2006.05.009.View ArticlePubMed
- Ives B, Sikes K, Urban A, Stephenson K, Tamborlane WV: Practical aspects of real-time continuous glucose monitors: the experience of the Yale Children’s Diabetes Program. Diabetes Educ. 2010, 36: 53-62. 10.1177/0145721709352010.PubMed CentralView ArticlePubMed
- Zijlstra E, Heise T, Nosek L, Heinemann L, Heckermann S: Continuous glucose monitoring: quality of hypoglycaemia detection. Diabetes Obes Metab. 2013, 15: 130-135. 10.1111/dom.12001.View ArticlePubMed
- Leelarathna L, Nodale M, Allen JM, Elleri D, Kumareswaran K, Haidar A, Caldwell K, Wilinska ME, Acerini CL, Evans ML: Evaluating the accuracy and large inaccuracy of two continuous glucose monitoring systems. Diabetes Technol Ther. 2013, 15: 143-149. 10.1089/dia.2012.0245.PubMed CentralView ArticlePubMed
- Damiano ER, El-Khatib FH, Zheng H, Nathan DM, Russell SJ: A comparative effectiveness analysis of three continuous glucose monitors. Diabetes Care. 2013, 36: 251-259. 10.2337/dc12-0070.PubMed CentralView ArticlePubMed
- Keenan DB, Mastrototaro JJ, Zisser H, Cooper KA, Raghavendhar G, Lee SW, Yusi J, Bailey TS, Brazg RL, Shah RV: Accuracy of the Enlite 6-day glucose sensor with guardian and Veo calibration algorithms. Diabetes Technol Ther. 2012, 14: 225-231. 10.1089/dia.2011.0199.View ArticlePubMed
- DexCom G4: Dexcom G4 PLATINUM User’s Guide. 2012, San Diego, CA,http://www.dexcom.com/sites/dexcom.com/files/dexcom-g4/docs/dexcomG4-UsersGuide-English-mmol24hr.pdf,
- Golicki DT, Golicka D, Groele L, Pankowska E: Continuous Glucose Monitoring System in children with type 1 diabetes mellitus: a systematic review and meta-analysis. Diabetologia. 2008, 51: 233-240. 10.1007/s00125-007-0884-9.View ArticlePubMed
- Chetty VT, Almulla A, Odueyungbo A, Thabane L: The effect of continuous subcutaneous glucose monitoring (CGMS) versus intermittent whole blood finger-stick glucose monitoring (SBGM) on hemoglobin A1c (HBA1c) levels in Type I diabetic patients: a systematic review. Diabetes Res Clin Pract. 2008, 81: 79-87. 10.1016/j.diabres.2008.02.014.View ArticlePubMed
- Beck RW, Buckingham B, Miller K, Wolpert H, Xing D, Block JM, Chase HP, Hirsch I, Kollman C, Laffel L: Factors predictive of use and of benefit from continuous glucose monitoring in type 1 diabetes. Diabetes Care. 2009, 32: 1947-1953.View ArticlePubMed
- Beck RW, Hirsch IB, Laffel L, Tamborlane WV, Bode BW, Buckingham B, Chase P, Clemons R, Fiallo-Scharer R, Fox LA: The effect of continuous glucose monitoring in well-controlled type 1 diabetes. Diabetes Care. 2009, 32: 1378-1383.View ArticlePubMed
- Battelino T, Phillip M, Bratina N, Nimri R, Oskarsson P, Bolinder J: Effect of continuous glucose monitoring on hypoglycemia in type 1 diabetes. Diabetes Care. 2011, 34: 795-800. 10.2337/dc10-1989.PubMed CentralView ArticlePubMed
- Kordonouri O, Pankowska E, Rami B, Kapellen T, Coutant R, Hartmann R, Lange K, Knip M, Danne T: Sensor-augmented pump therapy from the diagnosis of childhood type 1 diabetes: results of the Paediatric Onset Study (ONSET) after 12 months of treatment. Diabetologia. 2010, 53: 2487-2495. 10.1007/s00125-010-1878-6.View ArticlePubMed
- Slover RH, Welsh JB, Criego A, Weinzimer SA, Willi SM, Wood MA, Tamborlane WV: Effectiveness of sensor-augmented pump therapy in children and adolescents with type 1 diabetes in the STAR 3 study. Pediatr Diabetes. 2012, 13: 6-11. 10.1111/j.1399-5448.2011.00793.x.View ArticlePubMed
- Scaramuzza AE, Iafusco D, Rabbone I, Bonfanti R, Lombardo F, Schiaffini R, Buono P, Toni S, Cherubini V, Zuccotti GV: Use of integrated real-time continuous glucose monitoring/insulin pump system in children and adolescents with type 1 diabetes: a 3-year follow-up study. Diabetes Technol Ther. 2011, 13: 99-103. 10.1089/dia.2010.0119.View ArticlePubMed
- Frontino G, Bonfanti R, Scaramuzza A, Rabbone I, Meschi F, Rigamonti A, Battaglino R, Favalli V, Bonura C, Sicignano S: Sensor-augmented pump therapy in very young children with type 1 diabetes: an efficacy and feasibility observational study. Diabetes Technol Ther. 2012, 14: 762-764. 10.1089/dia.2012.0044.View ArticlePubMed
- Battelino T, Conget I, Olsen B, Schutz-Fuhrmann I, Hommel E, Hoogma R, Schierloh U, Sulli N, Bolinder J: The use and efficacy of continuous glucose monitoring in type 1 diabetes treated with insulin pump therapy: a randomised controlled trial. Diabetologia. 2012, 55: 3155-3162. 10.1007/s00125-012-2708-9.PubMed CentralView ArticlePubMed
- Lehecka KE, Renukuntla VS, Heptulla RA: Insight into hypoglycemia in pediatric type 1 diabetes mellitus. Int J Pediatr Endocrinol. 2012, 2012: 19-10.1186/1687-9856-2012-19.PubMed CentralView ArticlePubMed
- Wiltshire EJ, Newton K, McTavish L: Unrecognised hypoglycaemia in children and adolescents with type 1 diabetes using the continuous glucose monitoring system: prevalence and contributors. J Paediatr Child Health. 2006, 42: 758-763. 10.1111/j.1440-1754.2006.00973.x.View ArticlePubMed
- Hermanides J, DeVries JH: Sense and nonsense in sensors. Diabetologia. 2010, 53: 593-596. 10.1007/s00125-009-1649-4.PubMed CentralView ArticlePubMed
- Hirsch IB, Abelseth J, Bode BW, Fischer JS, Kaufman FR, Mastrototaro J, Parkin CG, Wolpert HA, Buckingham BA: Sensor-augmented insulin pump therapy: results of the first randomized treat-to-target study. Diabetes Technol Ther. 2008, 10: 377-383. 10.1089/dia.2008.0068.View ArticlePubMed
- Ly TT, Nicholas JA, Retterath A, Davis EA, Jones TW: Analysis of glucose responses to automated insulin suspension with sensor-augmented pump therapy. Diabetes Care. 2012, 35: 1462-1465. 10.2337/dc12-0052.PubMed CentralView ArticlePubMed
- Agrawal P, Welsh JB, Kannard B, Askari S, Yang Q, Kaufman FR: Usage and effectiveness of the low glucose suspend feature of the Medtronic Paradigm Veo insulin pump. J Diabetes Sci Technol. 2011, 5: 1137-1141.PubMed CentralView ArticlePubMed
- Cauza E, Hanusch-Enserer U, Strasser B, Ludvik B, Kostner K, Dunky A, Haber P: Continuous glucose monitoring in diabetic long distance runners. Int J Sports Med. 2005, 26: 774-780. 10.1055/s-2004-830561.View ArticlePubMed
- Riddell MC, Milliken J: Preventing exercise-induced hypoglycemia in type 1 diabetes using real-time continuous glucose monitoring and a new carbohydrate intake algorithm: an observational field study. Diabetes Technol Ther. 2011, 13: 819-825. 10.1089/dia.2011.0052.View ArticlePubMed
- Garg S, Brazg RL, Bailey TS, Buckingham BA, Slover RH, Klonoff DC, Shin J, Welsh JB, Kaufman FR: Reduction in duration of hypoglycemia by automatic suspension of insulin delivery: the in-clinic ASPIRE study. Diabetes Technol Ther. 2012, 14: 205-209. 10.1089/dia.2011.0292.View ArticlePubMed
- Heinemann L: The diabetes technologist: a practical solution in dealing with technology in everyday practice?. J Diabetes Sci Technol. 2012, 6: 1240-1241.PubMed CentralView ArticlePubMed
- CDTC Credential Program.http://clinicaldiabetestechnology.org/index.shtml,
- Cengiz E, Sherr JL, Weinzimer SA, Tamborlane WV: New-generation diabetes management: glucose sensor-augmented insulin pump therapy. Expert Rev Med Devices. 2011, 8: 449-458. 10.1586/erd.11.22.PubMed CentralView ArticlePubMed
- Weinzimer S, Xing D, Tansey M, Fiallo-Scharer R, Mauras N, Wysocki T, Beck R, Tamborlane W, Ruedy K: Prolonged use of continuous glucose monitors in children with type 1 diabetes on continuous subcutaneous insulin infusion or intensive multiple-daily injection therapy. Pediatr Diabetes. 2009, 10: 91-96.View ArticlePubMed
- Gilliam LK, Hirsch IB: Practical aspects of real-time continuous glucose monitoring. Diabetes Technol Ther. 2009, 11 (Suppl 1): S75-82.PubMed
- Chase HP: Understanding insulin pumps & continuous glucose monitors. 2nd Ed. edition. 2010, Childrens Diabetes Foundation: Denver, CO
- Buckingham B, Xing D, Weinzimer S, Fiallo-Scharer R, Kollman C, Mauras N, Tsalikian E, Tamborlane W, Wysocki T, Ruedy K, Beck R: Use of the DirecNet Applied Treatment Algorithm (DATA) for diabetes management with a real-time continuous glucose monitor (the FreeStyle Navigator). Pediatr Diabetes. 2008, 9: 142-147.View ArticlePubMed
- Orzeck EA: Maximizing reimbursement through correct coding initiatives. Diabetes Technol Ther. 2009, 11 (Suppl 1): S121-127.PubMed
- DeVries JH: Continuous glucose monitoring: coming of age?. Eur J Endocrinol. 2012, 166: 1-4. 10.1530/EJE-10-1127.View ArticlePubMed
- Wadwa RP, Fiallo-Scharer R, Vanderwel B, Messer LH, Cobry E, Chase HP: Continuous glucose monitoring in youth with type 1 diabetes. Diabetes Technol Ther. 2009, 11 (Suppl 1): S83-91.PubMed
- Mauras N, Beck R, Xing D, Ruedy K, Buckingham B, Tansey M, White NH, Weinzimer SA, Tamborlane W, Kollman C: A randomized clinical trial to assess the efficacy and safety of real-time continuous glucose monitoring in the management of type 1 diabetes in young children aged 4 to <10 years. Diabetes Care. 2012, 35: 204-210. 10.2337/dc11-1746.PubMed CentralView ArticlePubMed
- Pinsker JE, Nguyen C, Young S, Fredericks GJ, Chan D: A pilot project for improving paediatric diabetes outcomes using a website: the Pediatric Diabetes Education Portal. J Telemed Telecare. 2011, 17: 226-230. 10.1258/jtt.2010.100812.View ArticlePubMed
- Marling CR, Shubrook JH, Vernier SJ, Wiley MT, Schwartz FL: Characterizing blood glucose variability using new metrics with continuous glucose monitoring data. J Diabetes Sci Technol. 2011, 5: 871-878.PubMed CentralView ArticlePubMed
This article is published under license to BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.