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Table 4 Biochemistry results at baseline and after 3 months and 3 years

From: Weight loss on stimulant medication: how does it affect body composition and bone metabolism? – A prospective longitudinal study

 

Baseline

3 months

3 years

(n=25-31)

(n=17-25)

(n=9-15)

Albumin (g/L)

45.1 ± 3.7

46.5 ± 3.2*

46.1 ± 4.1

Prealbumin (g/L)

0.19 ± 0.04

0.19 ± 0.04

0.20 ± 0.04

Ferritin (ug/L)

28.0 ± 12.6

33.0 ± 13.5

31.4 ± 9.4

Transferrin (g/L)

2.61± 0.30

2.59 ± 0.39

2.63 ± 0.37

Glucose (mmol/L)

4.55 ± 0.35

4.52 ± 0.39

4.57 ± 0.63

Insulin (uU/mL)

4.23 ± 2.92

3.72 ± 2.37

3.07 ± 3.22

Leptin (ng/mL)

4.45 ± 4.03

2.73 ± 2.03*

3.13 ± 1.77

Ghrelin (pmol/L)

385 ± 143

461 ± 135

378 ± 204

IGF-1 (nmol/L)

19.7 ± 7.3

18.0 ± 7.3

31.1 ± 18.0*

IGFBP-3 (ug/mL)

4.07 ± 1.08

4.02 ± 0.87

5.82 ± 2.75*

P1NP (ng/mL)

554 ± 176

458 ± 93*

620 ± 264

C telopeptides (pg/mL)

0.545 ± 0.205

0.504 ± 0.169

0.886 ± 0.518*

Osteocalcin (ng/mL)

50.9 ± 21.9

54.4 ± 13.7

80.9 ± 22.2**

Parathyroid hormone (pmol/L)

1.40 ± 0.96

1.22 ± 0.62

1.99 ± 1.22

Vitamin D (nmol/L)

67.6 ± 23.0

71.6 ± 21.4

69.1 ± 15.8

  1. Mean ± standard deviation shown.
  2. * p<0.05 **p<0.01 compared to baseline, paired t-test.
  3. P1NP: propeptide of type I collagen; IGF-1: insulin-like growth factor 1; IGFBP-3: insulin-like growth factor binding protein 3; Vitamin D: 25-hydroxy vitamin D;
  4. There were significant reductions in P1NP, leptin and albumin in the first 3 months. Over 3 years there were significant increases in IGF-1, IGFBP-3, and C telopeptides and osteocalcin.
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International Journal of Pediatric Endocrinology

ISSN: 1687-9856

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